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The elimination half-life averages seven hours in manThe primary route of excretion is in the urinemostly in the form of metabolites.

The risk of GI bleedingulceration or perforation is higher with increasing NSAID dosesin patients with a history of ulcerparticularly if complicated with haemorrhage or perforationsee section 4.3and in the elderlyThese patients should commence treatment on the lowest dose availableCombination therapy with protective agentse.gmisoprostol or proton pump inhibitorsshould be considered for these patientsand also for patients requiring concomitant low dose aspirinor other drugs likely to increase gastrointestinal risksee below and section 4.5)

Anti-coagulantsNSAIDs may enhance the effects of anti-coagulantssuch as warfarinsee section 4.4)

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